Effect Roleptic of Hyperprolactinemia Induced Agent, Timiperone, on Porphyrin of Mouse Harderian Gland by Neu-

Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice.

PURPOSE To determine whether prolactin receptor is essential for normal development and function of the lacrimal gland and whether hyperprolactinemia can alter lacrimal development. METHODS Lacrimal gland morphology and function were examined in two genetic mouse models of prolactin action: a prolactin receptor knockout model that is devoid of prolactin action and a transgenic model of hyperp...

Fluorescence Studies on Cancer* I. Porphyrin Metabolism, Harderian Gland Fluorescence, and Susceptibility to Carcinogenic Agents

It is well known that different species (8, 14, 35, 36, 44) and different organs and tissues (45) vary greatly in their susceptibility to carcinogenic agents. The only animals that have been extremely susceptible to the induction of tumors by means of physical and pure chemical agents are mice and rats. It has been found difficult and frequently impossible to produce tumors by the same methods ...

Secretory response to light in rat Harderian gland: possible photoprotective role of Harderian porphyrin.

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

Proper regulation of intracellular levels of protoporphyrin IX (PPIX), the direct precursor of heme, is important for cell survival. A deficiency in ferrochelatase, which mediates the final step in heme biosynthesis, leads to erythropoietic protoporphyria (EPP), a photosensitivity syndrome caused by the accumulation of PPIX in the skin. We have previously shown that mice with a deficiency in th...

Proteome profiling in the rat Harderian gland.

The Harderian gland is an orbital gland located behind the ocular bulb in most terrestrial vertebrates probably functioning for production of lipid secretion to protect the eye. We herein present a protein reference database of the rat Harderian gland that may serve as analytical tool for future proteomic work, report lipid and porphyrin handling cascades, address sequence conflicts and report ...